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Testosterone is an androgenic and anabolic hormone secreted by the testes in men. Women also secrete some through the ovaries, and some is also produced by the adrenal glands. Testosterone is primarily a male hormone, and thus men produce about 40 to 60 percent more than women. While male and female muscle tissue is identical, testosterone is responsible for greater muscle size and strength in men.
The development of muscle in your body is somewhat limited due to a combination of your unique genetic disposition and the demands you put on your body. You can change the demands you put on your body by participating in a weight-training program, but genetically limitations may prevent you from achieving the muscle size you desire. According to exercise scientist Len Kravitz of the University of New Mexico, specific proteins called growth factors, growth hormone, cortisol and testosterone all influence your capacity to increase muscle size.
Testosterone provides a number of primary and secondary sexual characteristics. First, it is crucial for the continued production of sperm and virility in men. Along with helping to develop reproductive features and ensure virility, testosterone is also responsible for secondary affects like increased muscle mass and retention. Masculinizing men with typical masculine features, testosterone can aid in both increasing strength and decreasing things like osteoporosis. It’s function as a steroid hormone means that it will aid in bone density as well as things like bone maturation. It also helps things like deepening of the voice as well as growing hair on different parts of the body. Rates of testosterone in men are far above the amount for women. In men, it is typical for there to be hundreds of units of difference between individuals. If there is a masculine trait, it no doubt at one time or another has been blamed on testosterone
One of the first researchers and scientists to discover testosterone was Arnold Adolph Berthold. Through experimentation on fowls, he discovered that there were effects in the blood caused by the removal of testosterone creators. This research would lay the foundation for everything to come. Two researches at Harvard University took this even further by isolating testosterone and then attempting to market it as a ‘rejuvenation elixir.’ This not only helped to popularize the idea of testosterone, but also make it the subject of research for decades to come. Research published on taking testosterone stated that while an individual would feel wonderful, the effects would only last for a short amount of time. Disappointed that there was not more progress, research stopped for some time.
In 1927, research continued again as a Physiologic Chemistry professor began to isolate cow testosterone. He worked on creating a solution that created masculinizing effects on animals even if they had no reproductive organs capable of producing their own testosterone. This research was further expanded on by a research group in Amsterdam that extracted testosterone from cows and began researching the potential uses of it in closer detail. However, it was not until the 1930’s that serious investigation began across Europe. Full scale research by pharmaceutical companies led to the first production and access to testosterone by average individuals.
In 1935, the term ‘testosterone’ was given by a researcher named Organon. Working on the structure of the hormone, researchers chemically synthesized testosterone from cholesterol. With research occuring the world over, Both Butenandt and Ruzicka received the joint Chemistry Nobel Prize. Made in 1939, the discovery would herald in a new century of understanding regarding how we operate.
Research would soon discover that among other things, testosterone was responsible for the retention of nitrogen in the muscles. This increased nitrogen retention was linked to better anabolic activities. Testosterone was soon linked to anabolic activities in women, eunuchs and boys. Adding to past discoveries, the golden age of steroid research was about to begin.
Between 1930 and 1950, research on steroids entered what many considered to be the ‘golden age.’ Quickly progressing, researchers found many different qualities of testosterone and greatly improved the existing research on the subject. A lot of the findings were based on showing that testosterone increased muscle strength, wellbeing, and health of those who used them. It would not be long before synthetic testosterones and steroids would be created for use by the masses.
Testosterone Produced In the Body
As we stated at the beginning, testosterone is primarily created in the Leydig cells in the testicles of men. Creating a regular hormone cycle known as the HPTA cycle (hypothalamic-pituitary-testicular), it operates in the following way. The hypothalamus is responsible for detecting what the level of testosterone is in the body. If and when the level of testosterone in the body falls below a certain amount, the hypothalamus is responsible for secreting a gonadotropin release hormone (known as GnRH.) The purpose of the GnRH is to stimulate the pituitary gland to release a stimulating hormones into the system. These hormones are responsible for stimulating the testicles to produce testosterone through the Leydig cells.
The entire cycle will come to an end when the hypothalamus detects the hormone level to be at or above what is should be. At this point, the hypothalamus will stop secreting the GnHR leading to the pituitary gland to stop releasing its stimulating hormones. This is known as a negative feedback loop. It is specifically designed to maintain a balance within the body and to ensure that the level never goes above or beyond a certain amount. What the range is and how long the body can sustain that range will depend greatly on the physiology of the individual and it can range dramatically depending on who you are.
Testosterone travels through the body by binding to a protein. This is called the Sex Hormone Binding Globulin (also known as SHBG.) When bound up like this, it cannot take part in any other functions save for what it is designed to do. As a result, it is completely useless for pretty much any other purpose. What a person requires is having freely circulating testosterone. Unbound, this freely circulating testosterone can bind and do additional masculinizing affects like muscle growth. The more that SHBG levels increase in the body, the less free floating Testosterone there will be in the body. As it turns out, too much of a good thing results in bad side effects.